The 1200 Patients Project
The 1200 Patients Project aims to develop a new model for personalized medical care through preemptive pharmacogenomics. Enrolled patients provide a single blood sample for analysis, which is genotyped by an in-house CLIA-certified laboratory. Patients’ genetic information is compared to a database of well-substantiated pharmacogenomic research compiled by the 1200 Patients Project team, which is constantly updated to reflect the most current research available. This database is used to determine whether it is likely that a patient will respond positively or negatively to a medication.
The ACCOuNT Project
The African-American Cardiovascular Pharmacogenomics Consortium (ACCOuNT) is an NIH-supported, multi-institutional group of physicians, researchers, and patients whose goal is to reduce disparity in precision medicine, particularly for African-Americans. The ACCOuNT Translational project aims to explore the feasibility of implementing preemptive pharmacogenomic result delivery for African-Americans in the inpatient setting across multiple institutions. The ACCOuNT Translational project is led by principal investigator Dr. Peter O’Donnell (University of Chicago) and site leads Drs. Kevin O’Leary (Northwestern University) and Edith Nutescu (University of Illinois at Chicago).
The goal of the ImPreSS Trial is to develop a model of implementing point-of-care pharmacogenomic decision support in the perioperative care setting. Anesthesiologists and critical care and pain management physicians and associated providers (nurse anesthetists, physician assistants, and pharmacists) within the Department of Anesthesia and Critical Care (DACC) will be targeted for enrollment through a process of direct stakeholder engagement and informed consent. Adult patients with planned elective inpatient or outpatient surgeries will be eligible for the study. Enrolled patients provide a blood sample during their pre-operative clinic at the Anesthesia Perioperative Medicine Clinic (APMC), which is sent to our CLIA-certified laboratory for genotyping, and results will be available before the patient’s surgical admission. Patients’ genotyping results will be delivered to providers through our online web portal, the Genomic Prescribing System (GPS), which is currently integrated into our institutional electronic medical record.