Goals of Pharmacogenomics Research

The Center for Personalized Therapeutics researches pharmacogenomics on two levels: Discovery and Implementation.  Pharmacogenomic discovery research seeks to find new genetic associations that affect patient responses to medications.  For example, CPT members identified a variant within the KDR gene that affects patient rsponse to pazopanib, a cancer medication.  Implementation research, on the other hand, attempts to find ways to utilize pharmacogenomic discovery research in the clinic.  The 1200 Patients Project is an example of implementation research.  In this project, we have synthesized previous pharmacogenomic research to build an online Genomic Prescribing System (GPS) to be used by clinicians so that they can easily use patients' genetic information when making medication decisions.